Horizon Patient Services offers ongoing support for people with urea cycle disorders

Horizon Patient Services logo

Horizon Patient Services is dedicated to improving the lives of people living with UCDs. The Horizon Patient Services program provides ongoing individualized support and education for you and your family. Your Patient Access Manager (PAM) leads your dedicated Horizon Patient Services team that is here to help you, from answering questions as you start taking RAVICTI® (glycerol phenylbutyrate) Oral Liquid and through every step along the way. Your PAM is available in person or by email, text, or phone with information and guidance. To contact a PAM, call 1-833-830-RARE (1-833-830-7273) . These comprehensive services are free of charge and built around three components: coordinate, connect, and champion.

Your Horizon Patient Services team will:

Coordinate:
  • Work with you and your doctor’s office to simplify the process of getting started on RAVICTI
  • Help address financial barriers by researching your insurance benefits, finding out what your insurance will cover, explaining your insurance options, and connecting you to financial assistance options
  • Assist in connecting with your specialty pharmacy to schedule the shipment of your medicine so that you avoid running out of supply
Patient Access Manager group image
Connect:
  • Connect you and your family to others living with urea cycle disorders, live events, and online resources
  • Provide helpful tools and resources to manage the day-to-day challenges of living with a UCD
  • Introduce you and your family to UCD advocacy groups for more support and inform you of UCD events in your area
Champion:
  • Serve as your dedicated personal resource and the main point of contact for your ongoing RAVICTI logistical needs
  • Provide urea cycle disorder education and answer non-clinical-related questions
  • Help you through changes along the way that may impact your treatment
  • Respond to your questions and concerns, and connect you with the right resources to get answers

Talk to your Patient Access Manager (PAM) today. To get started with your PAM, download this form and call 1-833-830-RARE (1-833-830-7273). The form is also available in Spanish.

Additional support is available online through other UCD Community organizations.

Your RAVICTI Patient Starter Kit includes:

RAVICTI patient starter kit
  • A travel bag for safety and convenience
  • Sample blue AdaptaCap™ Bottle Adapter to help avoid spills
  • Sample dosing syringe to make RAVICTI easy to take
  • Easy-to-understand instructions for taking RAVICTI
  • Helpful information about UCDs and RAVICTI

To help you get started after you are prescribed RAVICTI for your urea cycle disorder, you'll receive a free RAVICTI Patient Starter Kit from your PAM.

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Patricia, UCD patient and caregiver
Patricia, UCD patient and caregiver

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UCD families are here to help

You don’t have to feel alone because you or your loved one is living with a urea cycle disorder (UCD). UCD patients and caregivers know what you’re going through because they live with UCDs every day, too. They’re here to answer your questions and support you during your treatment with RAVICTI.

Watch the videos to meet UCD patients and caregivers now.

Meet Patricia

My son and I both have a UCD. The challenges of being both caregiver and a patient can be quite a lot.

Read transcript

Patricia:

The challenges of being both the caregiver and a patient who has urea cycle disorder: that can be quite a lot.

My name is Patricia.

I’m a mom. I’m a wife. And I’m a caregiver. I have UCD, and my son also has urea cycle disorder.

We have a ornithine transcarbamylase deficiency.

I first learned that I had a urea cycle disorder when my son was diagnosed.

When you first get that diagnosis of a urea cycle disorder, it feels like your world has been turned upside down.

I have to say, though, that as devastating as the diagnosis was, it was a little bit of a relief.

I felt hope because for the first time so many unanswered things throughout my life and my family’s life finally made sense.

As a parent with a child with urea cycle disorder, you tend to have a little bit more on your plate.

The one thing I would say to that caregiver is, “Don’t lose hope. You can do this. There are many people, like myself, who are here, ready to help. You’re not alone.”

It’s hard at the end to take a little time away for yourself. But if you can’t take care of yourself, how can you take care of the ones you love?

I became a mentor because I feel like it’s the least I can do to pay it forward.

I would love to be able to help somebody walk this walk.

I’m a UCD mentor.

I’m here for you.

Let’s talk.

IMPORTANT SAFETY INFORMATION

Approved Uses for RAVICTI® (glycerol phenylbutyrate) Oral Liquid
RAVICTI is a prescription medicine used in adults and children 2 months of age and older for long-term management of high levels of ammonia in the blood (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI must be used along with a low-protein diet and, in some cases, dietary supplements. RAVICTI should only be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone.

RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crises) in people with UCDs as they may require rapidly acting medication.
It is not known if RAVICTI is safe and effective for the treatment of N-acetylglutamate synthase (NAGS) deficiency.
It is not known if RAVICTI is safe and effective for children younger than 2 months.


Detailed Important Safety Information

Who should not take RAVICTI:
Children younger than 2 months should not take RAVICTI because they may not be able to digest it. Do not take RAVICTI if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you have symptoms of an allergic reaction, such as wheezing, shortness of breath, cough, low blood pressure, flushing, nausea, or rash while taking RAVICTI.

RAVICTI may cause serious side effects:
The breakdown of RAVICTI produces the byproduct phenylacetate, which may cause nervous system side effects. Call your doctor or get medical help right away if you have any of these symptoms while taking RAVICTI: sleepiness; lightheadedness; change in taste; problems with hearing; confusion; problems with memory; worsening of numbness, tingling, or burning in your hands or feet; headache, tiredness; nausea; or vomiting.

What are the possible side effects of RAVICTI?
The most common side effects of RAVICTI in adults include diarrhea, gas, headache, nausea, vomiting, tiredness, decreased appetite, and dizziness.

The most common side effects of RAVICTI in children ages 2 to 17 years include stomach pain, nausea, vomiting, diarrhea, decreased appetite, and headache.

The most common side effects of RAVICTI in children ages 2 months to younger than 2 years include decreased level of a type of white blood cell, vomiting, diarrhea, fever, decreased appetite, cough, nasal congestion, runny nose, and rash.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of RAVICTI. Call your doctor for medical advice about side effects.

Before you take RAVICTI:
Tell your doctor if you have liver or kidney problems, pancreas or bowel (intestine) problems, or any other medical conditions. Tell your doctor if you are pregnant or plan to become pregnant. It is not known if RAVICTI will harm your unborn baby. Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if RAVICTI passes into your breast milk. Breastfeeding is not recommended during treatment with RAVICTI. Talk to your doctor about the best way to feed your baby if you take RAVICTI.

Talk to your doctor about participating in a UCD registry. The purpose of this registry is to collect information about people with UCDs to improve care. For more information about the registry program, call 1-855-823-2595 or visit www.ucdregistry.com.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

This information is not comprehensive. To learn more, talk to your healthcare provider or pharmacist. The FDA-approved product labeling, including the Medication Guide, can be found at Ravicti.com.

Meet Patricia, a UCD caregiver and patient

Experiences may not be typical. UCDs can manifest in different ways and at different times in a patient's life.

Meet David

There’s no one who really understands unless they've done that and been there.

Read transcript

David:

We have hope. We have a community. The hardest thing about UCD is not knowing real people that are going through it. And, with the mentor program, you’ll be able to talk to another person.

I’m David,

and I’m a caregiver for my wife and son, who have urea cycle disorder.

I learned about Isaac having UCD when he was 8 years old. He started getting lethargic and started not feeling well. He started getting worse and worse. And so we drove him to the emergency room.

And 4 hours later, my son’s in critical condition.

So it was at that point that he was diagnosed.

So we started getting treatment for it. And the doctor turns to my wife, and goes, “And you? Has anyone treated you? Because it’s X-linked. It’s handed from moms down to the children.”

And all of a sudden, it’s just like, oh, my gosh, this is what we’ve been wrestling with. It, it was, it was the world opened up. By getting the diagnosis, it sounds weird, because they’re saying, “You’re sick.” But to get the diagnosis was a relief.

There’s no one who really understands unless someone that has done that and been there. And that’s why I’m making myself available if some people just need to talk. If nothing else, I understand.

My son’s now in college. My wife is getting more lovely every year, and we’ve been at it for 30 years. We’re looking forward to what’s in front of us.

We’ll treat this every single day. But we won’t let it conquer us.

I am a mentor.

I am here for you.

Let's talk

IMPORTANT SAFETY INFORMATION

Approved Uses for RAVICTI® (glycerol phenylbutyrate) Oral Liquid
RAVICTI is a prescription medicine used in adults and children 2 months of age and older for long-term management of high levels of ammonia in the blood (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI must be used along with a low-protein diet and, in some cases, dietary supplements. RAVICTI should only be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone.

RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crises) in people with UCDs as they may require rapidly acting medication.
It is not known if RAVICTI is safe and effective for the treatment of N-acetylglutamate synthase (NAGS) deficiency.
It is not known if RAVICTI is safe and effective for children younger than 2 months.


Detailed Important Safety Information

Who should not take RAVICTI:
Children younger than 2 months should not take RAVICTI because they may not be able to digest it. Do not take RAVICTI if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you have symptoms of an allergic reaction, such as wheezing, shortness of breath, cough, low blood pressure, flushing, nausea, or rash while taking RAVICTI.

RAVICTI may cause serious side effects:
The breakdown of RAVICTI produces the byproduct phenylacetate, which may cause nervous system side effects. Call your doctor or get medical help right away if you have any of these symptoms while taking RAVICTI: sleepiness; lightheadedness; change in taste; problems with hearing; confusion; problems with memory; worsening of numbness, tingling, or burning in your hands or feet; headache, tiredness; nausea; or vomiting.

What are the possible side effects of RAVICTI?
The most common side effects of RAVICTI in adults include diarrhea, gas, headache, nausea, vomiting, tiredness, decreased appetite, and dizziness.

The most common side effects of RAVICTI in children ages 2 to 17 years include stomach pain, nausea, vomiting, diarrhea, decreased appetite, and headache.

The most common side effects of RAVICTI in children ages 2 months to younger than 2 years include decreased level of a type of white blood cell, vomiting, diarrhea, fever, decreased appetite, cough, nasal congestion, runny nose, and rash.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of RAVICTI. Call your doctor for medical advice about side effects.

Before you take RAVICTI:
Tell your doctor if you have liver or kidney problems, pancreas or bowel (intestine) problems, or any other medical conditions. Tell your doctor if you are pregnant or plan to become pregnant. It is not known if RAVICTI will harm your unborn baby. Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if RAVICTI passes into your breast milk. Breastfeeding is not recommended during treatment with RAVICTI. Talk to your doctor about the best way to feed your baby if you take RAVICTI.

Talk to your doctor about participating in a UCD registry. The purpose of this registry is to collect information about people with UCDs to improve care. For more information about the registry program, call 1-855-823-2595 or visit www.ucdregistry.com.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

This information is not comprehensive. To learn more, talk to your healthcare provider or pharmacist. The FDA-approved product labeling, including the Medication Guide, can be found at Ravicti.com.

Meet David, a UCD Caregiver

Experiences may not be typical. UCDs can manifest in different ways and at different times in a patient's life.

Meet Isaac

I definitely think when I started to take care of myself, my parents felt a lot more confident in letting me do my own thing.

Read transcript

Isaac:

Growing up with a UCD was interesting, to say the least. I got a much different perspective than a lot of other kids. I always had to be careful. I had to stay in. I was homeschooled. So, I’d say I got a lot more creativity than most people.

I’m Isaac,

and I’m living with OTC.

My family consists of me; my father, David; and my mother, Patricia.

Right now, I’m just taking the core program in a community college, in order to take all the basic classes like math, history, English, and all that.

I’m hoping to get into the video game design business. So I’m hoping to become a game designer.

I learned the hard way that I had UCD. It’s just a whole series of events that led to me actually falling into a coma that lasted for a week straight, and when I woke up, I was told that I had UCD.

It’s something I’ve been living with my entire life. It’s part of my everyday routine. At some point, you just say, “Well, just bring on life. I’m ready to take you on.”

I definitely think when I started to take care of myself, my parents felt a lot more confident in letting me do my own thing, that I was more of an adult, I was proving that I was able to take care of myself, handle myself. I knew what I was doing.

You’re your own biggest ally in this.

I became a UCD mentor because I feel like there are people out there that do need help and need to have someone to rely on and to give them some advice, and all of that. So with the experience I had, I figured it might be helpful for me to throw my hat into the ring.

I’m a mentor.

I’m here for you.

Let’s talk.

IMPORTANT SAFETY INFORMATION

Approved Uses for RAVICTI® (glycerol phenylbutyrate) Oral Liquid
RAVICTI is a prescription medicine used in adults and children 2 months of age and older for long-term management of high levels of ammonia in the blood (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI must be used along with a low-protein diet and, in some cases, dietary supplements. RAVICTI should only be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone.

RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crises) in people with UCDs as they may require rapidly acting medication.
It is not known if RAVICTI is safe and effective for the treatment of N-acetylglutamate synthase (NAGS) deficiency.
It is not known if RAVICTI is safe and effective for children younger than 2 months.


Detailed Important Safety Information

Who should not take RAVICTI:
Children younger than 2 months should not take RAVICTI because they may not be able to digest it. Do not take RAVICTI if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you have symptoms of an allergic reaction, such as wheezing, shortness of breath, cough, low blood pressure, flushing, nausea, or rash while taking RAVICTI.

RAVICTI may cause serious side effects:
The breakdown of RAVICTI produces the byproduct phenylacetate, which may cause nervous system side effects. Call your doctor or get medical help right away if you have any of these symptoms while taking RAVICTI: sleepiness; lightheadedness; change in taste; problems with hearing; confusion; problems with memory; worsening of numbness, tingling, or burning in your hands or feet; headache, tiredness; nausea; or vomiting.

What are the possible side effects of RAVICTI?
The most common side effects of RAVICTI in adults include diarrhea, gas, headache, nausea, vomiting, tiredness, decreased appetite, and dizziness.

The most common side effects of RAVICTI in children ages 2 to 17 years include stomach pain, nausea, vomiting, diarrhea, decreased appetite, and headache.

The most common side effects of RAVICTI in children ages 2 months to younger than 2 years include decreased level of a type of white blood cell, vomiting, diarrhea, fever, decreased appetite, cough, nasal congestion, runny nose, and rash.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of RAVICTI. Call your doctor for medical advice about side effects.

Before you take RAVICTI:
Tell your doctor if you have liver or kidney problems, pancreas or bowel (intestine) problems, or any other medical conditions. Tell your doctor if you are pregnant or plan to become pregnant. It is not known if RAVICTI will harm your unborn baby. Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if RAVICTI passes into your breast milk. Breastfeeding is not recommended during treatment with RAVICTI. Talk to your doctor about the best way to feed your baby if you take RAVICTI.

Talk to your doctor about participating in a UCD registry. The purpose of this registry is to collect information about people with UCDs to improve care. For more information about the registry program, call 1-855-823-2595 or visit www.ucdregistry.com.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

This information is not comprehensive. To learn more, talk to your healthcare provider or pharmacist. The FDA-approved product labeling, including the Medication Guide, can be found at Ravicti.com.

Meet Isaac, a UCD patient

Experiences may not be typical. UCDs can manifest in different ways and at different times in a patient's life.

Meet Amy

To be a mother of a child with a rare disease, you have to find your own voice.

Read transcript

Amy:

They always say, “It takes a village to raise a child.” Raising a child with a rare disease, I always tell people, “In my case, it takes a small army.”

My name’s Amy, and I’m a UCD mentor.

I used to have hobbies. Now, I have kids.

We have 2 kids. Ah, TJ. And then there’s Mya. They are twins.

We have 2 kids. Ah, TJ. And then there’s Mya. They are twins.

We first learned that Mya had a UCD when she was 6 months old. They always tell twin moms, “Don’t compare your kids.” But I had, uh, one, my son, who ate all the time and was healthy and happy, and I had my daughter, who was fussy all the time, and she would spit up, and I just knew something was wrong.

So I pushed the pediatrician, and he did some tests. They told us, “It appears your daughter is in liver failure.” Then, they. determined it must have been a virus. They sent us home. In about a week, the doctors called me and said, “It’s possible it’s this really rare genetic disorder, this urea cycle disorder, so we’re gonna test her for that.” And we got the results about 3 days later.

So Mya has OTC deficiency.

And I was, like, OK, at least now we know what she has. And now we can deal with it.

The doctors and nurses are amazing, but you know your child best. You can’t be afraid to tell ‘em that.

To be a mother of a child with a rare disease, you have to find your own voice, and you have to not be afraid to use it.

I always tell folks, “You can’t give up. You absolutely cannot give up.”

It’s gonna be hard. It’s gonna be exhausting, but you can do it. Your child can do it. And you’re not alone. You have resources. Don’t be afraid to reach out. And when people offer you help, take it.

I’m a mentor.

I’m here for you.

Let’s talk.

IMPORTANT SAFETY INFORMATION

Approved Uses for RAVICTI® (glycerol phenylbutyrate) Oral Liquid
RAVICTI is a prescription medicine used in adults and children 2 months of age and older for long-term management of high levels of ammonia in the blood (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI must be used along with a low-protein diet and, in some cases, dietary supplements. RAVICTI should only be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone.

RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crises) in people with UCDs as they may require rapidly acting medication.
It is not known if RAVICTI is safe and effective for the treatment of N-acetylglutamate synthase (NAGS) deficiency.
It is not known if RAVICTI is safe and effective for children younger than 2 months.


Detailed Important Safety Information

Who should not take RAVICTI:
Children younger than 2 months should not take RAVICTI because they may not be able to digest it. Do not take RAVICTI if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you have symptoms of an allergic reaction, such as wheezing, shortness of breath, cough, low blood pressure, flushing, nausea, or rash while taking RAVICTI.

RAVICTI may cause serious side effects:
The breakdown of RAVICTI produces the byproduct phenylacetate, which may cause nervous system side effects. Call your doctor or get medical help right away if you have any of these symptoms while taking RAVICTI: sleepiness; lightheadedness; change in taste; problems with hearing; confusion; problems with memory; worsening of numbness, tingling, or burning in your hands or feet; headache, tiredness; nausea; or vomiting.

What are the possible side effects of RAVICTI?
The most common side effects of RAVICTI in adults include diarrhea, gas, headache, nausea, vomiting, tiredness, decreased appetite, and dizziness.

The most common side effects of RAVICTI in children ages 2 to 17 years include stomach pain, nausea, vomiting, diarrhea, decreased appetite, and headache.

The most common side effects of RAVICTI in children ages 2 months to younger than 2 years include decreased level of a type of white blood cell, vomiting, diarrhea, fever, decreased appetite, cough, nasal congestion, runny nose, and rash.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of RAVICTI. Call your doctor for medical advice about side effects.

Before you take RAVICTI:
Tell your doctor if you have liver or kidney problems, pancreas or bowel (intestine) problems, or any other medical conditions. Tell your doctor if you are pregnant or plan to become pregnant. It is not known if RAVICTI will harm your unborn baby. Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if RAVICTI passes into your breast milk. Breastfeeding is not recommended during treatment with RAVICTI. Talk to your doctor about the best way to feed your baby if you take RAVICTI.

Talk to your doctor about participating in a UCD registry. The purpose of this registry is to collect information about people with UCDs to improve care. For more information about the registry program, call 1-855-823-2595 or visit www.ucdregistry.com.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

This information is not comprehensive. To learn more, talk to your healthcare provider or pharmacist. The FDA-approved product labeling, including the Medication Guide, can be found at Ravicti.com.

Meet Amy, a UCD caregiver

Experiences may not be typical. UCDs can manifest in different ways and at different times in a patient's life.

Meet Lauren

You're not alone. You have resources. Don't be afraid to reach out.

Read transcript

Lauren:

I remember growing up thinking and feeling that the only UCD people in the whole world were me and my mama, and that was, that was it. But now, I know that’s not true. There are so many people that have UCDs. I want ‘em to know that they have people out there that have been through the same experience that they have been through.

My name is Lauren, and I’m living with a UCD.

I have the most common type, which is OTC, which stands for ornithine transcarbamylase.

Well, I’m an only child. So, it’s my parents and me. It’s just the 3 of us.

I think that the most important thing I’ve learned from them is to just never give up, ecause with this diagnosis of a urea cycle disorder, they never gave up on finding answers. And they’re very fierce advocates for me.

I just feel like I’m here to live the best life I can. I want people to see that even though you have a UCD, you can do so many things.

Just because you have a urea cycle disorder doesn’t mean you can’t live a fulfilled life.

It’s just a part of who you are. It’s not your identity. It’s just something you deal with.

To hear experiences from other people, it makes me feel like I’m not by myself. It makes you feel like you have somebody that understands you, that gets your little quirky little ways, that all these other people, they don’t, they don’t quite get.

I want people, whenever they get this UCD diagnosis to know, you’ve got a lot of hope. You got a lot of resources available to you. And this is doable. You can live a healthy, functional life. Even though you have this, this diagnosis, you can do it, and if you have any questions, I’m here.

I’m a mentor.

I’m here for you.

Let’s talk.

IMPORTANT SAFETY INFORMATION

Approved Uses for RAVICTI® (glycerol phenylbutyrate) Oral Liquid
RAVICTI is a prescription medicine used in adults and children 2 months of age and older for long-term management of high levels of ammonia in the blood (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI must be used along with a low-protein diet and, in some cases, dietary supplements. RAVICTI should only be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone.

RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crises) in people with UCDs as they may require rapidly acting medication.
It is not known if RAVICTI is safe and effective for the treatment of N-acetylglutamate synthase (NAGS) deficiency.
It is not known if RAVICTI is safe and effective for children younger than 2 months.


Detailed Important Safety Information

Who should not take RAVICTI:
Children younger than 2 months should not take RAVICTI because they may not be able to digest it. Do not take RAVICTI if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you have symptoms of an allergic reaction, such as wheezing, shortness of breath, cough, low blood pressure, flushing, nausea, or rash while taking RAVICTI.

RAVICTI may cause serious side effects:
The breakdown of RAVICTI produces the byproduct phenylacetate, which may cause nervous system side effects. Call your doctor or get medical help right away if you have any of these symptoms while taking RAVICTI: sleepiness; lightheadedness; change in taste; problems with hearing; confusion; problems with memory; worsening of numbness, tingling, or burning in your hands or feet; headache, tiredness; nausea; or vomiting.

What are the possible side effects of RAVICTI?
The most common side effects of RAVICTI in adults include diarrhea, gas, headache, nausea, vomiting, tiredness, decreased appetite, and dizziness.

The most common side effects of RAVICTI in children ages 2 to 17 years include stomach pain, nausea, vomiting, diarrhea, decreased appetite, and headache.

The most common side effects of RAVICTI in children ages 2 months to younger than 2 years include decreased level of a type of white blood cell, vomiting, diarrhea, fever, decreased appetite, cough, nasal congestion, runny nose, and rash.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of RAVICTI. Call your doctor for medical advice about side effects.

Before you take RAVICTI:
Tell your doctor if you have liver or kidney problems, pancreas or bowel (intestine) problems, or any other medical conditions. Tell your doctor if you are pregnant or plan to become pregnant. It is not known if RAVICTI will harm your unborn baby. Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if RAVICTI passes into your breast milk. Breastfeeding is not recommended during treatment with RAVICTI. Talk to your doctor about the best way to feed your baby if you take RAVICTI.

Talk to your doctor about participating in a UCD registry. The purpose of this registry is to collect information about people with UCDs to improve care. For more information about the registry program, call 1-855-823-2595 or visit www.ucdregistry.com.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

This information is not comprehensive. To learn more, talk to your healthcare provider or pharmacist. The FDA-approved product labeling, including the Medication Guide, can be found at Ravicti.com.

Meet Lauren, a UCD patient

Experiences may not be typical. UCDs can manifest in different ways and at different times in a patient's life.

APPROVED USES and IMPORTANT SAFETY INFORMATION for RAVICTI
What is the most important safety information I should know about RAVICTI?
RAVICTI may cause serious side effects, including: Nervous system side effects (Neurotoxicity).
 The breakdown of RAVICTI produces the byproduct phenylacetate (PAA), which may cause nervous system side effects.

expand + close

What is RAVICTI?

RAVICTI (glycerol phenylbutyrate) Oral Liquid is a prescription medicine used for long-term management of high blood levels of ammonia (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI should be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone. RAVICTI must be used along with a low-protein diet and in some cases, dietary supplements.

RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crisis) in people with UCDs.

It is not known if RAVICTI is safe and effective for the treatment ofN-acetylglutamate synthase (NAGS) deficiency.

IMPORTANT SAFETY INFORMATION

What is the most important safety information I should know about RAVICTI?

RAVICTI may cause serious side effects, including:

Nervous system side effects (Neurotoxicity). The breakdown of RAVICTI produces the byproduct phenylacetate (PAA), which may cause nervous system side effects.

Call your doctor or get medical help right away if you have any of these symptoms while taking RAVICTI:

  • sleepiness
  • lightheadedness
  • change in taste
  • problems with hearing
  • confusion
  • problems with memory
  • worsening of numbness, tingling, or burning in your hands or feet
  • headache
  • feeling very tired (fatigue)
  • nausea
  • vomiting

Who should not take RAVICTI?

Do not take RAVICTI if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you experience any of the following symptoms of an allergic reaction while taking RAVICTI:

  • wheezing
  • shortness of breath
  • cough
  • low blood pressure
  • flushing
  • nausea
  • skin rash

What should I tell my doctor before taking RAVICTI?

Tell your doctor about any medical conditions and if you:

  • Have liver or kidney problems.
  • Have pancreas or bowel (intestine) problems.
  • Are pregnant or plan to become pregnant. It is not known if RAVICTI will harm your unborn baby.
    • Pregnancy Registry: There is a Pregnancy Registry for women who take RAVICTI just before becoming pregnant or who become pregnant during treatment with RAVICTI. The purpose of this registry is to collect information about the health of you and your baby. Talk to your doctor about how you can join the Pregnancy Registry. For more information about this registry, call 1-855-823-2595 or visit www.ucdregistry.com.
  • Are breastfeeding or plan to breastfeed. It is not known if RAVICTI passes into your breast milk. Breastfeeding is not recommended during treatment with RAVICTI. Talk to your doctor about the best way to feed your baby if you take RAVICTI.

What are possible side effects of RAVICTI?

RAVICTI may cause serious side effects, including:

  • See "What is the most important information I should know about RAVICTI?"

The most common side effects of RAVICTI in adults include:

  • diarrhea
  • gas
  • headache
  • abdomen (stomach) pain
  • vomiting
  • tiredness
  • decreased appetite
  • indigestion or heartburn

The most common side effects of RAVICTI in children 2 years to 17 years of age include:

  • upper abdomen (stomach) pain
  • rash
  • nausea
  • vomiting
  • diarrhea
  • decreased appetite
  • headache

The most common side effects of RAVICTI in children 2 months to less than 2 years of age include:

  • low white blood cell count (neutropenia)
  • vomiting
  • diarrhea
  • fever
  • reduced food intake
  • cough
  • stuffy nose
  • runny nose
  • skin rash
  • small round bumps on the skin

The most common side effects of RAVICTI in children less than 2 months of age include:

  • vomiting
  • rash
  • gastroesophageal reflux
  • increased levels of liver enzymes in the blood
  • decreased appetite and reduced food intake
  • low red blood cell count (anemia)
  • cough
  • loss of too much body fluid (dehydration)
  • too much acid in the blood (acidosis)
  • high blood platelet count (thrombocytosis)
  • low blood platelet count (thrombocytopenia)
  • low blood neutrophil count (type of white blood cell) (neutropenia)
  • high white blood cell count (lymphocytosis)
  • diarrhea
  • gas
  • constipation
  • fever
  • drowsiness (lethargy)
  • irritability
  • agitation

These are not all of the possible side effects of RAVICTI. Call your doctor for medical advice about side effects.

For additional important safety information, click here for the Full Prescribing Information and Medication Guide and discuss with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

What is RAVICTI?

RAVICTI (glycerol phenylbutyrate) Oral Liquid is a prescription medicine used for long-term management of high blood levels of ammonia (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI should be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone. RAVICTI must be used along with a low-protein diet and in some cases, dietary supplements.

RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crisis) in people with UCDs.

It is not known if RAVICTI is safe and effective for the treatment ofN-acetylglutamate synthase (NAGS) deficiency.

IMPORTANT SAFETY INFORMATION

What is the most important safety information I should know about RAVICTI?

RAVICTI may cause serious side effects, including:

Nervous system side effects (Neurotoxicity). The breakdown of RAVICTI produces the byproduct phenylacetate (PAA), which may cause nervous system side effects.

Call your doctor or get medical help right away if you have any of these symptoms while taking RAVICTI:

  • sleepiness
  • lightheadedness
  • change in taste
  • problems with hearing
  • confusion
  • problems with memory
  • worsening of numbness, tingling, or burning in your hands or feet
  • headache
  • feeling very tired (fatigue)
  • nausea
  • vomiting

Who should not take RAVICTI?

Do not take RAVICTI if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you experience any of the following symptoms of an allergic reaction while taking RAVICTI:

  • wheezing
  • shortness of breath
  • cough
  • low blood pressure
  • flushing
  • nausea
  • skin rash

What should I tell my doctor before taking RAVICTI?

Tell your doctor about any medical conditions and if you:

  • Have liver or kidney problems.
  • Have pancreas or bowel (intestine) problems.
  • Are pregnant or plan to become pregnant. It is not known if RAVICTI will harm your unborn baby.
    • Pregnancy Registry: There is a Pregnancy Registry for women who take RAVICTI just before becoming pregnant or who become pregnant during treatment with RAVICTI. The purpose of this registry is to collect information about the health of you and your baby. Talk to your doctor about how you can join the Pregnancy Registry. For more information about this registry, call 1-855-823-2595 or visit www.ucdregistry.com.
  • Are breastfeeding or plan to breastfeed. It is not known if RAVICTI passes into your breast milk. Breastfeeding is not recommended during treatment with RAVICTI. Talk to your doctor about the best way to feed your baby if you take RAVICTI.

What are possible side effects of RAVICTI?

RAVICTI may cause serious side effects, including:

  • See "What is the most important information I should know about RAVICTI?"

The most common side effects of RAVICTI in adults include:

  • diarrhea
  • gas
  • headache
  • abdomen (stomach) pain
  • vomiting
  • tiredness
  • decreased appetite
  • indigestion or heartburn

The most common side effects of RAVICTI in children 2 years to 17 years of age include:

  • upper abdomen (stomach) pain
  • rash
  • nausea
  • vomiting
  • diarrhea
  • decreased appetite
  • headache

The most common side effects of RAVICTI in children 2 months to less than 2 years of age include:

  • low white blood cell count (neutropenia)
  • vomiting
  • diarrhea
  • fever
  • reduced food intake
  • cough
  • stuffy nose
  • runny nose
  • skin rash
  • small round bumps on the skin

The most common side effects of RAVICTI in children less than 2 months of age include:

  • vomiting
  • rash
  • gastroesophageal reflux
  • increased levels of liver enzymes in the blood
  • decreased appetite and reduced food intake
  • low red blood cell count (anemia)
  • cough
  • loss of too much body fluid (dehydration)
  • too much acid in the blood (acidosis)
  • high blood platelet count (thrombocytosis)
  • low blood platelet count (thrombocytopenia)
  • low blood neutrophil count (type of white blood cell) (neutropenia)
  • high white blood cell count (lymphocytosis)
  • diarrhea
  • gas
  • constipation
  • fever
  • drowsiness (lethargy)
  • irritability
  • agitation

These are not all of the possible side effects of RAVICTI. Call your doctor for medical advice about side effects.

For additional important safety information, click here for the Full Prescribing Information and Medication Guide and discuss with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.