TranscendRare services offer ongoing support for people with urea cycle disorders

TranscendRare™, a HorizonCares program, is dedicated to improving the lives of people living with urea cycle disorders (UCDs). The TranscendRare program provides a network of services and support for you and your family.

Your TranscendRare support team consists of a dedicated case manager and a patient access manager who will work closely with you at every step along your journey—from UCD education and treatment information to financial assistance and lifelong adherence support. These comprehensive services are free of charge and are built around 3 key principles: guide, support, and connect.

  • Work with your doctor’s office to simplify the process of getting you started on your medicine
  • Help address financial barriers for you by researching your insurance benefits, finding out what your insurance will cover, and connecting you to financial assistance options
  • Work with your specialty pharmacy to schedule the shipments of your medicine
  • Provide you with refill reminders for your prescription
  • Serve as your dedicated personal resource and main point of contact for your ongoing needs
  • Provide UCD education, and answer any treatment-related questions
  • Help you stay on therapy through any life changes, like moving or loss of insurance or employment
  • Respond to your questions and concerns, and connect you with the right resources to get answers
  • Connect you and your family to others living with UCDs through social media communities, peer mentor programs, and live events
  • Provide you with helpful resources to help manage the day-to-day challenges of living with a UCD
  • Introduce you and your family to UCD advocacy groups for more support

Visit to learn more about the resources and tools Horizon provides to you and your family through the TranscendRare program. You can also call 1-855-823-7878 to reach the TranscendRare representatives supporting UCD patients.

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Important Safety information

Ravicti® (glycerol phenylbutyrate) oral liquid indications and usage

Approved Uses for RAVICTI® (glycerol phenylbutyrate) Oral Liquid

RAVICTI is a prescription medicine used in adults and children 2 months of age and older for long-term management of high levels of ammonia in the blood (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI must be used along with a low-protein diet and, in some cases, dietary supplements. RAVICTI should only be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone.

RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crises) in people with UCDs as they may require rapidly acting medication.

It is not known if RAVICTI is safe and effective for the treatment of N-acetylglutamate synthase (NAGS) deficiency.

It is not known if RAVICTI is safe and effective for children younger than 2 months.

Detailed Important Safety Information

Who should not take RAVICTI:

Children younger than 2 months should not take RAVICTI because they may not be able to digest it.

Do not take RAVICTI if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you have symptoms of an allergic reaction, such as wheezing, shortness of breath, cough, low blood pressure, flushing, nausea, or rash while taking RAVICTI.

RAVICTI may cause serious side effects:

The breakdown of RAVICTI produces the byproduct phenylacetate, which may cause nervous system side effects. Call your doctor or get medical help right away if you have any of these symptoms while taking RAVICTI: sleepiness; lightheadedness; change in taste; problems with hearing; confusion; problems with memory; worsening of numbness, tingling, or burning in your hands or feet; headache, tiredness; nausea; or vomiting.

What are the possible side effects of RAVICTI?

The most common side effects of RAVICTI in adults include diarrhea, gas, headache, nausea, vomiting, tiredness, decreased appetite, and dizziness.

The most common side effects of RAVICTI in children ages 2 to 17 years include stomach pain, nausea, vomiting, diarrhea, decreased appetite, and headache.

The most common side effects of RAVICTI in children ages 2 months to younger than 2 years include decreased level of a type of white blood cell, vomiting, diarrhea, fever, decreased appetite, cough, nasal congestion, runny nose, and rash.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of RAVICTI. Call your doctor for medical advice about side effects.

Before you take RAVICTI:

Tell your doctor if you have liver or kidney problems, pancreas or bowel (intestine) problems, or any other medical conditions. Tell your doctor if you are pregnant or plan to become pregnant. It is not known if RAVICTI will harm your unborn baby. Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if RAVICTI passes into your breast milk. Breastfeeding is not recommended during treatment with RAVICTI. Talk to your doctor about the best way to feed your baby if you take RAVICTI.

Talk to your doctor about participating in a UCD registry. The purpose of this registry is to collect information about people with UCDs to improve care. For more information about the registry program, call 1-855-823-2595 or visit

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

This information is not comprehensive. To learn more, talk to your healthcare provider or pharmacist. The FDA-approved product labeling, including the Medication Guide can be found at